Principal Scientist, Translational Sciences

A typical mandate

The company is developing in vivo CAR-T approaches that engineer a patient's own T cells inside the body, without ex vivo manufacturing. Its lead program is in IND-enabling studies for an autoimmune indication. The team needs a translational scientist who can make the first clinical study informative.

What the role owns

• Design pharmacology and biomarker strategies that link animal models to human dosing
• Develop and qualify flow cytometry, ddPCR and cytokine assays for clinical use
• Lead nonclinical studies in humanized mouse and non-human primate models with CRO partners
• Author translational sections of the IND and investigator brochure
• Partner with clinical on sampling plans and pharmacodynamic endpoints
• Present findings to program teams and leadership

What great candidates bring

• PhD in immunology, molecular biology or a related field
• 6+ years of industry experience in cell therapy, gene therapy or immunology
• Hands-on experience with high-parameter flow cytometry and biomarker assay development
• Contribution to at least one IND submission
• Familiarity with LNP or viral vector delivery preferred
• Clear communication across research and clinical teams

Why it matters

• A visible role on the company's lead program
• Equity at Series B
• Lab-based role in one of the country's strongest cell and gene therapy communities
• A path to Associate Director as the program moves into the clinic